We are developing novel neuromodulation approaches for selective transcranial stimulation or inhibition of specific brain cell types, with a goal of translating these approaches into new therapies for pain and migraine.
Neural cell biology and pharmacology
We use imaging and electrophysiological techniques to investigate basic neuronal and glial cell biology and pharmacology. Recent studies have focused on cell-signaling in pain pathways, and on cortical neuronal and glial responses to pharmacological and non-pharmacological therapeutic targets for migraine and pain.
Neurovascular function and cortical spreading depression
We use optical and electrophysiological recordings to characterize spontaneous and evoked neurovascular signaling in anesthetized and freely behaving mice. Recent studies have focused on basic mechanisms of neurovascular coupling, pharmacological approaches to inhibiting cortical spreading depression, and the development of minimally invasive techniques for long-term recording and triggering of brain activity.
Representative video sequences shown below. For more videos, see Video Gallery page (link), or UCLA Goldberg Migraine Program Youtube Channel
Intercellular Calcium Signaling in Glial Cells
Calcium Responses of Cortical Neurons to NMDA
Calcium Signaling in Developing Neurons
Depression (CSD) in Mouse Brain
CSD - Digital Subtraction
Oscillations in Mouse Brain